Which medications in the drug class Analgesic, Opioid are used in the treatment of Premature Ejaculation?

Updated: May 25, 2021
  • Author: Samuel G Deem, DO; Chief Editor: Edward David Kim, MD, FACS  more...
  • Print

Analgesic, Opioid

Tramadol is an analgesic with centrally acting opioid activity (weak μ-opioid effect) in addition to inhibition of reuptake of 5-HT and norepinephrine. It is hypothesized that the increased synaptic content of serotonin and norepinephrine at the level of the spinal cord and peripheral sensory nerves provides the mechanism for effective treatment of premature ejaculation.

Tramadol (Ultram, Rybix ODT, ConZip, Ryzolt)

Tramadol is a centrally acting opioid analgesic that exerts its effect by combining opioid receptor activation with inhibition of norepinephrine and serotonin reuptake. If there is no beneficial effect on premature ejaculation after 6 weeks or if adverse effects become troublesome, it should be discontinued in favor of an alternative treatment. Treatment of premature ejaculation is an off-label use of tramadol.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!