What are adverse effects of long-term SSRI use for premature ejaculation (PE)?

Updated: Jan 15, 2019
  • Author: Samuel G Deem, DO; Chief Editor: Edward David Kim, MD, FACS  more...
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Adverse effects of long-term SSRI use are a significant concern and should be considered by both the physician and the patient. [41] Such adverse effects may include the following:

  • Psychiatric and neurologic sequelae

  • Dermatologic reactions

  • Anticholinergic effects

  • Fluctuation in body weight

  • Cognitive impairment

  • Drug interactions

  • Sexual side effects other than delayed ejaculation (eg, erectile dysfunction or loss of libido)

In addition, caution should be exercised in changing SSRIs; a washout period is necessary to avoid overdose. SSRI discontinuance syndrome (especially with paroxetine) has been associated with dose reduction or discontinuance and may cause dizziness, nausea and vomiting, headache, gait instability, lethargy, agitation, anxiety, and insomnia. [42]

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