What conditions must be considered in the differential diagnoses of premature ejaculation (PE)?

Updated: Jan 15, 2019
  • Author: Samuel G Deem, DO; Chief Editor: Edward David Kim, MD, FACS  more...
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Several other conditions must be considered in making a diagnosis of premature (early) ejaculation.

One such condition is severely delayed orgasm in the female partner. The term “delayed” is relative in this context; the average time to climax in females varies but averages 12-25 minutes, according to many studies, and 3 hours, for example, would be well outside the norm. In extreme cases of delayed or difficult orgasm in the female partner, almost any male would be considered to have premature ejaculation. The partner’s sexual response must always be taken into account.

Another such condition is an adverse effect from a psychotropic drug. If the premature ejaculation started in association with the commencement of psychotropic pharmacotherapy but ceased when the drug was withdrawn, one should strongly consider a relationship between the two events.

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