Which medications are used in the treatment of premature ejaculation (PE)?

Updated: Jan 15, 2019
  • Author: Samuel G Deem, DO; Chief Editor: Edward David Kim, MD, FACS  more...
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Pharmacologic therapy may include the following:

  • Topical desensitizing agents (eg, lidocaine and prilocaine) for the male

  • Selective serotonin reuptake inhibitor (SSRI) therapy (eg, sertraline, paroxetine, fluoxetine, citalopram, or dapoxetine); alternatively, use of an agent with SSRI-like effect

  • Phosphodiesterase type 5 (PDE5) inhibitor therapy (eg, sildenafil, tadalafil, or possibly vardenafil)

  • Other agents (eg, pindolol or tramadol)

No recommended surgical therapy exists.

See Treatment and Medication for more detail.

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