How has the definition and massive transfusion changed over time?

Updated: Apr 16, 2019
  • Author: Linda L Maerz, MD, FACS, FCCM; Chief Editor: Emmanuel C Besa, MD  more...
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The definition of massive transfusion has evolved over time to reflect modern transfusion practice. [21] Thirty years ago, massive transfusion was defined as more than 10 units of blood over 24 hours, roughly equivalent to one patient blood volume for an average weight person. Although one patient blood volume in 24 hours remains the “classic” definition, recent authors expand this definition to reflect up to 50 units of blood in 24-48 hours.

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