When is transfusion of cryoprecipitate indicated?

Updated: Apr 16, 2019
  • Author: Linda L Maerz, MD, FACS, FCCM; Chief Editor: Emmanuel C Besa, MD  more...
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Transfusion of cryoprecipitate is indicated for fibrinogen deficiency or dysfibrinogenemia in the setting of hemorrhage, invasive procedures, injury, or acute disseminated intravascular coagulation. Fibrinogen levels should be monitored and treatment undertaken for levels less than 100 mg/dL; many clinicians use a higher threshold of 150 mg/dL in patients with active hemorrhage. Cryoprecipitate is generally transfused in aliquots of 10 units. Patients on an MTP and receiving greater than 10 units of FFP generally do not need additional cryoprecipitate, having received an adequate bolus of fibrinogen in the large quantity of FFP.

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