What is the recommended initial FFP transfusion dosing?

Updated: Apr 16, 2019
  • Author: Linda L Maerz, MD, FACS, FCCM; Chief Editor: Emmanuel C Besa, MD  more...
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A guideline for initial FFP dosing is 10-15 mL/kg; this typically translates to at least 4 units of FFP to effect a therapeutic response. Efficacy is monitored by laboratory tests of coagulation function, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and the international normalized ratio (INR).  However, more recently, FFP is rarely indicated in vitamin K deficiency or reversal of warfarin therapy, because concentrates such as prothrombin complex concentrate are widely available. [15, 16] The exception is in the circumstance of concomitant plasma volume deficit.

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