When is transfusion of FFP indicated?

Updated: Apr 16, 2019
  • Author: Linda L Maerz, MD, FACS, FCCM; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

The transfusion of FFP is common, but the specific indications for its use are limited. In fact, evidence for its use in numerous clinical situations, such as prophylaxis in nonbleeding patients, is poor. [11, 12, 13, 14] FFP transfusion is indicated in hemorrhaging patients to replace labile and lost coagulation factors. Clinical circumstances fulfilling this criterion include massive transfusion, cardiopulmonary bypass, extracorporeal pulmonary support techniques, decompensated liver disease, or acute disseminated intravascular coagulation regardless of cause.

In the past, FFP, in conjunction with vitamin K, was also indicated for excessive warfarinization in circumstances accompanied by life-threatening hemorrhage. 


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