How is immunosuppression after solid organ transplantation maintained during pregnancy?

Updated: Jan 04, 2016
  • Author: Bethany Pellegrino, MD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Answer

Answer

Current data suggest that protocols involving cyclosporine, azathioprine, and steroids are associated with low rates of birth defects, although patients are treated with high-risk pregnancy strategies. However, also note that children born to parents with previous transplants are often small for gestational age. Preliminary data also suggest the safety of tacrolimus. Mycophenolate mofetil animal data and some early human studies show adverse effects on fetal development. Presently, few data exist regarding sirolimus and pregnancy.


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