What are the transfusion requirements for liver transplantation in alloimmunized patients?

Updated: Apr 19, 2019
  • Author: Vanessa A Olcese, MD, PhD; Chief Editor: Ron Shapiro, MD  more...
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Answer

Answer

Hemolysis secondary to alloimmunization can present a challenge in OLT, and it can greatly increase requirements for transfusion.

Weber and coworkers found that, compared with nonsensitized patients, those who were highly alloimmunized (from either multiple transfusions or pregnancy) required significantly more intraoperative blood products during OLT despite venovenous bypass without heparin. [35] Preoperative screening for lymphocytotoxicity can predict which patients will require additional blood products, both RBCs and platelets, during and after transplantation.


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