What are the transfusion requirements for liver transplantation in patients with hemophilia?

Updated: Apr 19, 2019
  • Author: Vanessa A Olcese, MD, PhD; Chief Editor: Ron Shapiro, MD  more...
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Answer

Answer

Until the introduction of viral inactivation techniques in the mid-1980s, plasma-derived clotting factor concentrates were sometimes contaminated with hepatitis C virus (HCV), and the vast majority of patients with hemophilia treated with these products were exposed to and infected with HCV. [33] As a result, many hemophiliac patients developed chronic hepatitis eventuating in cirrhosis and end-stage liver disease (ESLD). Liver transplantation in such cases can also result in a cure for hemophilia, [34] and 11 such cases have been reported. Hemophiliac patients require factor VIII or IX in addition to blood products when undergoing liver transplantation, and results have been good.

Unfortunately, many of these patients are also infected with HIV, so long-term life expectancy is poor. For those with HIV infection, a US National Institutes of Health study for liver transplantation is available that evaluated improved life expectancy, is available.


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