What are the transfusion requirements for liver transplantation in IgA-deficient patients?

Updated: Apr 19, 2019
  • Author: Vanessa A Olcese, MD, PhD; Chief Editor: Ron Shapiro, MD  more...
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Answer

Answer

IgA-deficient patients have circulating anti-IgA antibodies that attack IgA when it is present in their serum. IgA-deficient OLT recipients who require large volumes of blood during and after the procedure must be given IgA-deficient blood. This usually requires autologous plasmapheresis, manual washing of erythrocytes and platelets,or use of blood from severely IgA-deficient donors. Proper planning can ensure that IgA-deficient blood products are available for these patients.


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