What is graft dysfunction following lung transplantation?

Updated: Aug 19, 2019
  • Author: Bryan A Whitson, MD, PhD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Early graft dysfunction occurs within the first 24 hours after the transplant. It occurs in fewer than 10% of cases and is characterized histologically by diffuse alveolar damage. The dysfunction usually is the result of severe donor lung ischemia, donor lung injury, or vascular anastomotic stenosis. [42, 41]

Primary graft dysfunction

Primary graft dysfunction may result from ischemia-reperfusion injury. In patients with idiopathic pulmonary fibrosis, elevated pentraxin-3 levels seem to be associated with the development of primary graft dysfunction after lung transplantation. [50] Variants in the gene encoding pentraxin-3 are risk factors for primary graft dysfunction in lung transplant patients and are associated with increased plasma levels of pentraxin-3. [51]

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