What is the role of corticosteroids in lung transplantation?

Updated: Aug 19, 2019
  • Author: Bryan A Whitson, MD, PhD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Answer

Corticosteroids have various effects on the immune system, primarily mediated by their interaction with a high-affinity cytoplasmic steroid receptor. Prednisone, prednisolone, and methylprednisolone all are used for transplant patients. Intraoperatively, methylprednisolone is administered prior to the reperfusion of the grafted lung. Postoperatively, moderate doses of corticosteroids in combination with tacrolimus and MMF are used for the induction of immunosuppression. An oral dose of prednisone at 0.5 mg/kg/d usually is begun 5-7 days postoperatively.


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