What is the role of azathioprine in lung transplantation?

Updated: Aug 19, 2019
  • Author: Bryan A Whitson, MD, PhD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
  • Print
Answer

Azathioprine is a purine analog that is converted to several active metabolites, including 6-mercaptopurine. These metabolites have inhibitory effects on the hematologic proliferation of T cells and B cells. Azathioprine is begun at a dosage of 2-2.5 mg/kg/d, and the dose is adjusted to maintain a white blood cell (WBC) count of no less than 4000 cells/mm3.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!