What is the role of cyclosporine in lung transplantation?

Updated: Aug 19, 2019
  • Author: Bryan A Whitson, MD, PhD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Answer

Cyclosporine was the mainstay of immunosuppression before the introduction of tacrolimus. Serum levels of 300-400 mg/mL usually are maintained for the first month; thereafter, levels of 150-200 mg/mL are considered therapeutic. Nephrotoxicity, the major adverse effect of cyclosporine, results from vasoconstriction of the afferent glomerular arterioles.


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