What is the role of tacrolimus in lung transplantation?

Updated: Aug 19, 2019
  • Author: Bryan A Whitson, MD, PhD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Tacrolimus is a macrolide compound that binds to the immunophilin protein called the FK-binding protein, which then inhibits calcineurin within the cell. Tacrolimus has been used for immunosuppression as part of a 3-drug regimen taking the place of cyclosporine in many centers. Tacrolimus has been found to be superior to cyclosporine in lung transplantation in terms of decreased incidences of acute rejection and chronic rejection. [44] Toxicity of tacrolimus is similar to that of cyclosporine and includes renal dysfunction, hypertension, neurotoxicity, and glucose intolerance.

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