What is the role of lab tests in the workup of tumors of the mediastinum?

Updated: Feb 16, 2021
  • Author: Mary C Mancini, MD, PhD, MMM; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Answer

Serum chemical findings diagnostic for primary hyperparathyroidism can be observed when parathyroid adenoma or carcinoma develops within ectopic parathyroid glands in the mediastinum. These findings include elevated serum calcium levels associated with a decrease of serum phosphorus. Parathyroid hormone (PTH) levels are elevated.

In cases where no pathology is found in the neck, extend the evaluation of the cause of primary hyperparathyroidism to the mediastinum.

Functioning thyroid adenomas can develop in ectopic mediastinal thyroid tissue and can cause thyroid-stimulating hormone (TSH) suppression and associated elevation of serum triiodothyronine levels.


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