Which medications in the drug class Benzodiazepines are used in the treatment of Pneumothorax?

Updated: Apr 28, 2020
  • Author: Brian J Daley, MD, MBA, FACS, FCCP, CNSC; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Answer

Benzodiazepines

Benzodiazepines are used for conscious sedation. These agents are useful for premedication before pleurodesis/sclerotherapy or placement of a thoracostomy tube.

Midazolam

Benzodiazepine used for sedation component of conscious sedation protocol. Onset of action occurs within 1-5 min. Half-life of 1-4 h. Prolonged with liver cirrhosis, congestive heart failure, obesity, and old age.

Lorazepam (Ativan)

Lorazepam is a sedative hypnotic with a short onset of effects and a relatively long half-life. This drug acts by increasing the action of gamma aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. However, lorazepam may depress all levels of the central nervous system (CNS), including the limbic and reticular formations.

The initial adult dose is 2 mg total or 0.044 mg/kg IV, whichever is smaller. Alternatively, administer 0.05 mg/kg IV, not to exceed 4 mg/dose.

In children, the dose is 0.05-0.1 mg/kg IV slowly over 2-5 minutes; a slow 0.5 mg/kg IV dose may be repeated.


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