Which medications in the drug class Antibiotics are used in the treatment of Pneumothorax?

Updated: Apr 28, 2020
  • Author: Brian J Daley, MD, MBA, FACS, FCCP, CNSC; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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In patients with repeated pneumothoraces who are not good candidates for surgery, pleurodesis (or sclerotherapy) may be necessary. Two major sclerosing agents that can be used are talc and doxycycline. Prophylactic antibiotics are not recommended for the placement of chest tubes in nontraumatic causes.

Doxycycline (Vibramycin, Vibra-Tabs, Doryx)

Doxycycline is broad-spectrum, synthetically derived bacteriostatic antibiotic in the tetracycline class. It is almost completely absorbed, concentrates in bile, and is excreted in urine and feces as a biologically active metabolite in high concentrations.

Cefazolin (Kefzol)

Cefazolin is a first-generation cephalosporin. According to the Eastern Association for the Surgery of Trauma (EAST) Practice guidelines, a first-generation cephalosporin should be administered for no longer than 24 hours after tube thoracostomy.

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