Which conditions are associated with secondary spontaneous pneumothorax?

Updated: Apr 28, 2020
  • Author: Brian J Daley, MD, MBA, FACS, FCCP, CNSC; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Answer

Diseases and conditions associated with secondary spontaneous pneumothorax include the following:

  • Chronic obstructive lung disease (COPD) or emphysema - Increased pulmonary pressure due to coughing with a bronchial plug of mucus or phlegm bronchial plug may play a role.
  • Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) with PCP infection
  • Necrotizing pneumonia
  • Sarcoidosis
  • Bronchogenic carcinoma or metastatic malignancy
  • Idiopathic pulmonary fibrosis
  • Inhalational and intravenous drug use (eg, marijuana, cocaine) [9]
  • Interstitial lung diseases associated with connective tissue diseases
  • Lymphangioleiomyomatosis
  • Langerhans cell histiocytosis
  • Severe acute respiratory syndrome (SARS) - A reported 1.7% of SARS patients developed spontaneous pneumothorax. [10]
  • Thoracic endometriosis and catamenial pneumothorax
  • Collagen vascular disease, including Marfan syndrome

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