What is sickle cell disease (SCD)?

Updated: Jul 24, 2019
  • Author: Ivan Ramirez, MD; Chief Editor: Felix S Chew, MD, MBA, MEd  more...
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Sickle cell disease (SCD) is a chronic hemoglobinopathy of clinical relevance because of its significant morbidity and mortality, particularly in people of African and Mediterranean ancestry. SCD results from a mutated form of hemoglobin, hemoglobin S (HBS), and vascular obstruction and ischemia result in a wide range of clinical problems. [1, 2, 3, 4, 5]   Effects on the musculoskeletal system include extramedullary hematopoiesis, osteonecrosis, dactylitis (hand-foot syndrome), myonecrosis, and osteomyelitis,with bone disease being one of the most common presentations in patients with SCD. [6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16]

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