Why are synovial sarcomas the most frequently misdiagnosed soft-tissue carcinoma?

Updated: Mar 02, 2019
  • Author: Michael J Duh, MD; Chief Editor: Felix S Chew, MD, MBA, MEd  more...
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Answer

Answer

Synovial sarcoma tumors can appear small, especially those in the hands or head and neck regions, [17, 18, 19]  where they come to medical attention earlier. Often, the small size, well-defined margins, and sometimes homogeneous appearance of synovial sarcoma can lead to misdiagnosis as a benign lesion. Berquist et al found that synovial sarcoma was the malignant soft-tissue sarcoma most frequently misdiagnosed as benign. [20]  Small, superficial, solid lesions should be approached as a possible sarcoma unless strong signs prove otherwise. [2, 21]


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