What is the role of nuclear imaging in the workup of pleomorphic sarcoma (malignant fibrous histiocytoma) of soft tissue?

Updated: Nov 07, 2018
  • Author: Gregory Scott Stacy, MD; Chief Editor: Felix S Chew, MD, MBA, MEd  more...
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Technetium-99m bone scintigraphy often shows increased uptake by tumor, regardless of the presence of calcium within the tumor or invasion of adjacent bone. Hypervascular lesions show increased radionuclide uptake on both dynamic and blood pool images. The mildly increased uptake observed on static images is also probably related to hypervascularity and may be more prominent with internal calcification. Bone scans usually are not ordered to evaluate the primary tumor but may be obtained if osseous metastases are suggested. Gallium-67 scans may also demonstrate increased activity.

(See the images below.)

Spot image of a technetium-99m bone scintigram (de Spot image of a technetium-99m bone scintigram (delayed phase) reveals increased radiotracer uptake in the soft tissue tumor.
Gallium-67 scintigram reveals increased radiotrace Gallium-67 scintigram reveals increased radiotracer activity in the left thigh.
Technetium-99m bone scintigram (delayed phase) rev Technetium-99m bone scintigram (delayed phase) reveals increased radiotracer uptake in the left thigh.
Spot images from technetium-99m scintigram (blood Spot images from technetium-99m scintigram (blood pool phase) reveal increased radiotracer uptake in the left thigh.

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