Which findings on FDG-PET are characteristic of bone marrow involvement in thoracic non-Hodgkin lymphoma (NHL)?

Updated: Mar 05, 2019
  • Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: Eugene C Lin, MD  more...
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Bone marrow involvement indicates stage IV disease and carries a less favorable prognosis for patients with NHL. Focal and infiltrative osseous lesions can be detected on FDG-PET imaging. Infiltrative osseous lesions show a diffuse increase in bone marrow radioactivity, which appears greater than that of the liver. Bone marrow involvement in NHL can be detected on FDG-PET scans with a sensitivity of 81-88% and a specificity of 100%. On 99mTc methylene diphosphonate (MDP) scans, osseous NHL deposits may be photon deficient, and FDG-PET scanning has been shown to be superior. FDG-PET scanning depicts up to 42% more focal osseous lesions than does 99mTc MDP bone scintigraphy.

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