What is the sensitivity of CT scans for detecting liver and splenic involvement in thoracic non-Hodgkin lymphoma (NHL)?

Updated: Mar 05, 2019
  • Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: Eugene C Lin, MD  more...
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Answer

Answer

In NHL, liver and splenic involvement is seen in 15% and 22% of patients, respectively. Infiltrative involvement of the liver, spleen, and bone marrow cannot be accurately detected with CT, as organomegaly is a poor predictor of tumor involvement. In fact, approximately 30% of patients with splenic enlargement do not have malignant involvement. Sensitivity rates for CT are 15-37% for infiltrative splenic disease and 19-33% for infiltrative liver disease.


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