Which radiology findings are characteristic of large-B-cell and lymphoblastic mediastinal non-Hodgkin lymphoma (NHL)?

Updated: Mar 05, 2019
  • Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: Eugene C Lin, MD  more...
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The most common types of NHL to involve the mediastinum are large–B-cell lymphoma and lymphoblastic lymphoma. Parenchymal lung infiltration may occur in around 5% of cases, but this may be found without associated mediastinal lymphadenopathy. [21]

The plain radiographic finding of parenchymal lung involvement is also identical to that seen in HD. Multiple nodules are the most common features, but poorly defined opacification with an air bronchogram may also be seen. Features indistinguishable from pneumonic change, such as bilateral airspace consolidation and segmental or lobar atelectasis, are less common. Arora and colleagues reported on an uncommon case of diffuse histiocytic lymphoma that occurred with pulmonary miliary mottling that responded well to chemotherapy. [22]

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