What is the accuracy of CT scanning for the diagnosis of emphysema?

Updated: Mar 13, 2019
  • Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: Eugene C Lin, MD  more...
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Hruban et al [28] and Bergin C et al [29] have shown an excellent correlation between HRCT and histologic findings. They used low-resolution (10 mm) scans and were still able to show that CT findings were better predictors of emphysema than results of pulmonary function tests.

Semiautomated assessment of emphysema by using HRCT data is possible and can help eliminate interobserver and intraobserver variability and provide a reproducible assessment of the percentage of lung affected. Gould et al [30] measured the mean density in vivo of the lowest fifth percentile of the distribution of pixels and compared it with a computed quantification of emphysema on the subsequently excised lungs and identified a strong correlation between lung attenuation and distal airspace size.

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