When is radiologically isolated syndrome (RIS) diagnosed following an evaluation for multiple sclerosis (MS)?

Updated: Aug 07, 2018
  • Author: Djamil Fertikh, MD; Chief Editor: James G Smirniotopoulos, MD  more...
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Radiologically isolated syndrome (RIS) describes cases in which McDonald imaging criteria meet DIT and DIS but lack corresponding clinical symptoms. The exact significance is still a subject of debate. Some authors suggested that this could represent a stage preceding clinical isolated syndrome (CIS). In an extensive review of the RIS literature, Granberg et al [17] emphasized that approximately two thirds of cases show radiologic progression and one third develop clinical symptoms at 5-year follow-up. They also point out that clinical conversion is more likely when cervical cord lesions are present. However, further studies are needed to determine patient stratification and define the role of disease-modifying drugs in RIS.

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