What is the role of F18-FDG PET scanning in brain and CNS lymphoma imaging?

Updated: Feb 28, 2019
  • Author: Djamil Fertikh, MD; Chief Editor: James G Smirniotopoulos, MD  more...
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Thallium-201 single-photon emission computed tomography may demonstrate intense uptake of the radiotracer within tumor tissue. Carbon-11 methionine or 18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) may show increased uptake within the tumor tissue. [29, 30]  Because FDG-uptake on diffuse large B-cell lymphoma is higher than that on other types of lymphoma, it may be helpful in differentiating between primary central nervous system lymphoma (PCNSL) and gliomas. F18-FDG PET has been shown to have a diagnostic sensitivity in PCNSL of 76-100%. Maximum standardized uptake value (SUVmax) has been shown to be higher in PCNSL than in gliomas. Similarly, 18F-FDG PET can identify degenerative diseases, multiple sclerosis, infectious diseases, and cerebral infarction. [31]  F18-FDG PET/CT may have a role in the assessment of extra-cerebral disease. [32, 33]

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