How are brain and CNS lymphoma differentiated from other ring-enhancing lesions on MRI?

Updated: Feb 28, 2019
  • Author: Djamil Fertikh, MD; Chief Editor: James G Smirniotopoulos, MD  more...
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Care should be taken, especially in cases involving ring-enhancing lesions, to differentiate lymphoma from other disorders, such toxoplasmosis, cryptococcosis, gliomas, and metastasis; on MRI, the appearance of these disorders may be similar to that of lymphoma.

Involvement of the corpus callosum is highly suggestive of CNS lymphoma, but such involvement also occasionally occurs with anaplastic glioma and metastatic neoplasm.

A study by Xi et al found that arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE)-derived permeability parameters can help differentiate primary central nervous system lymphoma (PCNSL) from high-grade glioma (HGG) and brain metastasis. [28]

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