Which medications in the drug class Anti-CD20 Monoclonal Antibodies are used in the treatment of Polymyositis?

Updated: Jun 13, 2020
  • Author: Mythili Seetharaman, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Anti-CD20 Monoclonal Antibodies

Clinical trials with rituximab have shown encouraging results in patients who are refractory to first-line treatment.

Rituximab (Rituxan)

(Off-label) Rituximab is a humanized monoclonal antibody that binds to CD20 antigen, thereby inducing complement- or antibody-mediated cytolysis. Clinical trials in refractory polymyositis have shown improvement in patients who have failed corticosteroids and other immunosuppressive agents.


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