Why are inflammatory infiltrates missed in a muscle-biopsy specimen for evaluation of polymyositis?

Updated: Jan 05, 2021
  • Author: Mythili Seetharaman, MD; Chief Editor: Herbert S Diamond, MD  more...
  • Print

Because the inflammatory infiltrates can be small and multifocal, they can be missed in a small muscle-biopsy specimen. Perifascicular atrophy or prominent perivascular infiltrates are not present, and the blood vessels are normal. When the disease becomes chronic, the connective tissue increases. The diagnosis of polymyositis is definite when a patient has subacute, elevated levels of serum CK and findings on muscle biopsy consistent with the histologic features of polymyositis.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!