How does polymyositis affect the risk for amyotrophic lateral sclerosis (ALS)?

Updated: Feb 12, 2018
  • Author: Mythili Seetharaman, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Polymyositis shares pathologic characteristics and immunologic features with  amyotrophic lateral sclerosis (ALS), and a nationwide cohort study from Taiwan found that a diagnosis of polymyositis increased the likelihood of a subsequent diagnosis of ALS (P <0.001). The association was independent of sex, age, and concomitant autoimmune diseases. [12]


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