What are the prognostic factors for polymyositis?

Updated: Jan 05, 2021
  • Author: Mythili Seetharaman, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Poor prognostic factors include the following:

  • Advanced age
  • Female sex
  • African-American race
  • Interstitial lung disease
  • Presence of anti-Jo-1 (lung disease) and anti-SRP antibodies (severe muscle disease, cardiac involvement)
  • Associated malignancy
  • Delayed or inadequate treatment
  • Dysphagia, dysphonia
  • Cardiac and pulmonary involvement

Watanabe et al reported that negative assays for myositis-specific autoantibodies and the absence of severe muscle weakness requiring assistance at diagnosis are independent predictive factors for sustained remission in adult patients with polymyositis/dermatomyositis. [11]


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