What is the role of infection in the etiology of polymyositis?

Updated: Feb 12, 2018
  • Author: Mythili Seetharaman, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

An increased association of myositis has been found with human leukocyte antigen (HLA) haplotypes A1, B8, and DR3, which also increase the risk for autoimmune diseases. Environmental triggers, especially infectious agents, have been suggested as etiologic agents. These include the following:

  • Coxsackievirus B1
  • HIV
  • HTLV-1
  • Hepatitis B virus
  • Influenza
  • Echovirus
  • Adenovirus

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