Which proteins are targeted by myositis-specific antibodies (MSAs) in the pathogenesis of polymyositis?

Updated: Feb 12, 2018
  • Author: Mythili Seetharaman, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The identified MSA targets include the following 3 distinct groups of proteins:

  • Aminoacyl–transfer ribonucleic acid (tRNA) synthetases (anti-Jo-1)
  • Nuclear Mi-2 protein
  • Components of the signal-recognition particle (SRP)

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