Which medications in the drug class Proton pump inhibitors are used in the treatment of Mixed Connective-Tissue Disease (MCTD)?

Updated: Jan 21, 2021
  • Author: Eric L Greidinger, MD; Chief Editor: Herbert S Diamond, MD  more...
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Proton pump inhibitors

Esophageal reflux symptoms can be controlled effectively with these agents. Patients requiring long term PPIs should be co-managed with a gastroenterologist.

Omeprazole (Prilosec)

Inhibits gastric acid secretion by inhibition of the H+/K+ -ATPase enzyme system in gastric parietal cells. May be effective to treat reflux symptoms in MCTD. As in scleroderma, high dose PPI therapy may be needed.  Other Proton Pump Inhibitors are used with similar clinical efficacy.

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