What is the role of medications in the treatment of mixed connective-tissue disorder (MCTD)?

Updated: Oct 01, 2018
  • Author: Eric L Greidinger, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Arthritis/arthralgia can often be controlled with nonsteroidal anti-inflammatory drugs (NSAIDs) and hydroxychloroquine. Low-dose oral corticosteroids or low-dose methotrexate is reserved for more refractory synovitis. Proton pump inhibitors can control esophageal reflux symptoms. In patients with Raynaud phenomenon, calcium channel blocking agents are used. Phosphodiesterase inhibitors, endothelin receptor antagonists, or prostaglandins can be used for pulmonary hypertension.


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