Which immune studies are performed in the workup of mixed connective-tissue disorder (MCTD)?

Updated: Oct 01, 2018
  • Author: Eric L Greidinger, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Further results are as follows:

  • Antiphospholipid antibodies (including anticardiolipin antibodies and lupus anticoagulant) may be associated with pulmonary hypertension
  • Rheumatoid factor is frequently detected
  • Other lupus-specific antibodies (eg, anti–double-stranded DNA antibodies) are absent
  • Scleroderma-specific antibodies, including anticentromere, anti–Scl-70 (topoisomerase), and anti–PM-1 (Pm-Scl), are absent
  • C3 and C4 complement levels are more likely to be depleted in lupus than in MCTD

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