What is the role of lab tests in the workup of HIV-caused viral arthritis?

Updated: Nov 12, 2019
  • Author: Rabea Ahmed Khouqeer, MD, FRCPC, FAAAAI; Chief Editor: Herbert S Diamond, MD  more...
  • Print
Answer

In persons with HIV infection, laboratory abnormalities generally are common but nonspecific, including the following:

  • Elevated levels of serum immunoglobulins
  • Moderately elevated erythrocyte sedimentation rate (ESR)
  • Circulating immune complexes
  • Low-grade complement activation
  • Low-titer ANA
  • RF
  • False-positive test result for syphilis and anticardiolipin antibodies
  • Lupus anticoagulants
  • Possible detection of CD8 + T cells and P-24 antigen in synovial fluid

Human T-lymphotropic virus (HTLV-1) infection is diagnosed on the basis of detection of antibodies by means of enzyme-linked immunosorbent assay (ELISA), with confirmation by Western blot and the observation of “flower cells” on the peripheral smear.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!