What is the role of lab tests in the workup of parvovirus B19-caused viral arthritis?

Updated: Nov 12, 2019
  • Author: Rabea Ahmed Khouqeer, MD, FRCPC, FAAAAI; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The incubation period for parvovirus B19 is 7-18 days, and the state of viremia lasts 5-6 days. The following studies are indicated:

  • Complete blood count (CBC) to assess hemoglobin, neutrophils, and lymphocytes
  • Immunoglobulin M (IgM) antibody titer – High levels may be noted 4-6 days after the initial viremia
  • Viral B19 DNA by polymerase chain reaction (PCR)

The immunoglobulin G (IgG) antibody titer is of little diagnostic significance. Low-to-moderate titers for rheumatoid factor (RF), anti-DNA, antinuclear antibodies (ANAs), and anticardiolipin antibodies are possible in some patients.


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