What are considerations regarding drug therapy for amyloidosis?

Updated: May 09, 2019
  • Author: Robert O Holmes, Jr, DO; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Answer

Considerations regarding drug therapy include the following:

  • Certain medications such as digoxin or calcium channel blockers are dangerous to the already-hindered conduction system in cardiac amyloid.
  • Higher doses of angiotensin-converting enzyme inhibitors can also foster dangerous hypotension and are not recommended. [110]
  • Beta-blockers are relatively contraindicated in cardiac amyloidosis and are associated with a higher death rate. [113]
  • Amiodarone (200 mg PO q5d/wk) prevents arrhythmias and should be considered first and continued indefinitely. [114]

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