What is the role of bortezomib in the treatment of amyloidosis?

Updated: May 09, 2019
  • Author: Robert O Holmes, Jr, DO; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Answer

In AL amyloidosis, the proteasome inhibitor bortezomib has proved effective, especially as pretreatment before high-dose melphalan followed by autologous stem cell transplantation. A systematic review and meta-analysis found that the addition of bortezomib to treatment of AL amyloidosis resulted in significantly improved overall response rate (ORR), complete response, cardiac response rate, and 2-year overall survival; risk of neuropathy and overall mortality were both reduced. [108]


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