What is the role of doxycycline in the treatment of amyloidosis?

Updated: May 09, 2019
  • Author: Robert O Holmes, Jr, DO; Chief Editor: Herbert S Diamond, MD  more...
  • Print
Answer

Answer

A pilot study demonstrated reduction in arthralgia and increased range of motion with doxycycline treatment. The authors theorize that doxycycline inhibits β2-microglobulin fibrillogenesis and inhibits the accumulation in bone architecture. Their trial monitored long-term dialysis patients with severe amyloid arthropathy. Using a low dose of 100 mg of doxycycline daily, they were able to provide pain reduction, increased range of motion, and no adverse effects at 5 months. [102]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!