What is the incidence of amyloidosis?

Updated: May 09, 2019
  • Author: Robert O Holmes, Jr, DO; Chief Editor: Herbert S Diamond, MD  more...
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The incidence of amyloid associated with long-standing inflammatory disease may be decreasing with improved treatment to target strategies and focused biologic therapeutics. The overall incidence of various types of amyloidosis has declined over the last 10 years and can be directly linked to wider information sharing, prompt treatment of underlying disease, and increased used of disease-modifying therapy and targeted biological therapy. [92]

In Finland, the overall number of patients requiring renal replacement therapy in the setting of amyloidosis has decreased over 50% in 10 years, while the use of methotrexate has increased almost 4-fold. [93] This was the first study to prove this drop in amyloid-related renal disease, but the results were contrary to an earlier study that only showed the average age of amyloid-related renal disease was rising. [93] Investigational bias, however, may be confounding the incidence data, with a 2013 study showing the incidence renal amyloidosis may be rising. [94]

However, certain subsets of renal amyloid are decreasing, such as the HIV-related renal amyloid, which now only accounts for a fraction of HIV-related renal disease in the setting of widespread highly active antiretroviral therapy (HAART). [95]

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