What is the role of imaging in the diagnosis of amyloidosis?

Updated: May 09, 2019
  • Author: Robert O Holmes, Jr, DO; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Answer

Several modalities can help visualize amyloid deposits. Cardiac amyloidosis can be visualized with gated MRI and technetium pyrophosphate (99m Tc-PYP) scintography. [83] In some cases, scintography can distinguish AL from ATTR cardiac amyloidosis. [84]

Imaging techniques such as structural MRI and fluorodeoxyglucose (FDG) positron emission tomography (PET) can show structure and function pathology longitudinally, but "the extent and topographical distribution of Aβ deposition correlates relatively poorly with cognitive profile, severity or progression of the clinical deficit." [85]


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