What is Muckle-Wells syndrome (MWS)?

Updated: May 09, 2019
  • Author: Robert O Holmes, Jr, DO; Chief Editor: Herbert S Diamond, MD  more...
  • Print
Answer

Answer

MWS is another autoinflammatory syndrome secondary to a mutation in the CIAS gene encoding cryopyrin, a component of the inflammasome that regulates the processing of IL-1β. Patients commonly experience sensorineural hearing loss and other neuropathies. [57] The IL-1β receptor antagonist anakinra has been shown to improve the signs and symptoms in MWS by decreasing serum (hsCRP and SAA) and cytokines such as IL-6, IL-8, IL-12, and IL-1β. In some cases, it improved sensory deafness, as well as the laboratory values for markers of inflammation MWS. [58]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!