What is A amyloidosis (AA)?

Updated: May 09, 2019
  • Author: Robert O Holmes, Jr, DO; Chief Editor: Herbert S Diamond, MD  more...
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The precursor protein is a normal-sequence apo-SAA (serum amyloid A protein) now called "A", which is an acute phase reactant produced mainly in the liver in response to multiple cytokines. [5] "A" protein circulates in the serum bound to high-density lipoprotein.

AA occurs in various chronic inflammatory disorders, chronic local or systemic microbial infections, and occasionally with neoplasms; it was formerly termed secondary amyloidosis.. Worldwide, AA is the most common systemic amyloidosis, although the frequency has been shown to vary significantly in different ethnic groups. [9] Typical organs involved include the kidney, liver, and spleen. Some of the conditions associated with AA include the following:

  • Rheumatoid arthritis (RA) [10]

  • Alzheimer disease [11]

  • Multiple myeloma [12]

  • Juvenile idiopathic arthritis [13]

  • Ankylosing spondylitis [14]

  • Psoriasis and psoriatic arthritis [15]

  • Still disease [16]

  • Behçet syndrome [17]

  • Familial Mediterranean fever [18]

  • Crohn disease [19]

  • Leprosy [20]

  • Osteomyelitis [21]

  • Tuberculosis [22]

  • Chronic bronchiectasis [23]

  • Castleman disease [24]

  • Hodgkin disease and non-Hodgkin lymphoma [25]

  • Renal cell carcinoma [26]

  • Gastrointestinal, lung, or urogenital carcinoma [27]

  • Cryopyrin-associated periodic syndromes (CAPS) [28]

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