Is HCQ safe for pregnant women with rheumatoid arthritis (RA)?

Updated: May 11, 2018
  • Author: Katherine K Temprano, MD; Chief Editor: Christine Isaacs, MD  more...
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Answer

Answer

HCQ, an antimalarial agent, is considered a category C medication. Previous reports of fetal toxicity with this agent were based on the effects of chloroquine, which has 2.5 times the amount of tissue deposition as HCQ. No fetal toxicity is associated with HCQ at the dosage used for RA and connective-tissue disease (6.5 mg/kg body weight). [30] Several studies and case series have provided further evidence that no fetal toxicity is associated with HCQ therapy in mothers. [31, 32, 33]


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